周媛媛 講師
學(xué)歷學(xué)位：博士研究生 理學(xué)博士
導(dǎo)師類別：碩士生導(dǎo)師
聯(lián)系方式：zhouyy@fosu.edu.cn
研究方向
本人長(zhǎng)期從事疾病發(fā)病機(jī)理,，藥物活性評(píng)價(jià)及治療機(jī)制研究,，主要研究興趣在腫瘤免疫治療，抗腫瘤藥物活性，基于新型生物材料的藥物遞送系統(tǒng),。在相關(guān)領(lǐng)域以第一或通訊作者身份在Biomaterials, Frontier in Immunology, International Journal of Molecular Sciences, Phytomedicine等高影響力學(xué)術(shù)期刊發(fā)表論文10篇,，共發(fā)表學(xué)術(shù)論文20篇,，累計(jì)影響因子超過(guò)100,。博士后期間主持科研項(xiàng)目3項(xiàng)。獲發(fā)明專利2項(xiàng),。
學(xué)習(xí)與工作經(jīng)歷
（1）2006.09-2010.07：中國(guó)藥科大學(xué),，藥學(xué)專業(yè)本科生；
（2）2010.09-2013.07：中國(guó)藥科大學(xué),，藥物代謝動(dòng)力學(xué)專業(yè)碩士研究生,；
（3）2013.09-2015.06：香港理工大學(xué)深圳研究院，科研助理,；
（4）2015.07-2019.09：香港理工大學(xué),，生物學(xué)專業(yè)博士研究生；
（5）2020.05-2023.04：中山大學(xué),，博士后,；
（6）2023.05-至今： 佛山科學(xué)技術(shù)學(xué)院，講師,。
科研項(xiàng)目
[1] 主持校級(jí)基金，高?；究蒲袠I(yè)務(wù)費(fèi)青年教師培育項(xiàng)目,，《骨髓間充質(zhì)干細(xì)胞來(lái)源的外泌體通過(guò)miR-455-3p促進(jìn)骨關(guān)節(jié)炎軟骨修復(fù)的機(jī)制研究》，2022. 01至2022.12,，12.77萬(wàn)元,。
[2] 主持市級(jí)基金，博士后啟動(dòng)項(xiàng)目,，2024.01.01至2026.12.30,，30萬(wàn)元。
[3] 參與國(guó)家自然科學(xué)基金,，面上項(xiàng)目, 《鎂調(diào)控H型血管-感覺神經(jīng)生成耦聯(lián)效應(yīng)介導(dǎo)腱骨愈合的機(jī)制研究》,，2023-01-01 至 2026-12-31, 54萬(wàn)元。
[4] 主持企業(yè)委托項(xiàng)目,，《干細(xì)胞來(lái)源的外泌體用于治療骨關(guān)節(jié)炎的效果評(píng)價(jià)及機(jī)制研究》,，2024.7.9-2025.7.8，10萬(wàn)元,。
論文成果
[1].Sitong Liu, Chen Zhang, Yuanyuan Zhou, Fang Zhang, Xiaohui Duan, Yang Liu, Xibang Zhao, Jie Liu, Xintao Shuai, Jiali Wang, Zhong Cao, MRI-visible Mesoporous Polydopamine Nanoparticles with Enhanced Antioxidant Capacity for Osteoarthritis Therapy, Biomaterails, 2023, 295, 122030. (共同一作,，中科院一區(qū),， IF: 15.304)
[2].Zhongguo Zhou, Cao Tao, Jianting Li, Johnny Cheuk-on Tang, Albert Sun-chi Chan, and Yuanyuan Zhou*, Chimeric antigen receptor T cells applied to solid tumors, Frontier in Immunology, 2022,13. （通訊作者，JCR一區(qū),，IF: 8.786）
[3].Yuanyuan Zhou, Zhongguo Zhou, Dessy Chan, Po yee Chung, Yongqi Wang, Albert Sun chi Chan, Simon Law, Kim hung Lam, and Johnny Cheuk On Tang, The anticancer effect of a novel quinoline derivative 91b1 through downregulation of Lumican, International Journal of Molecular Sciences, 2022, 23(21): p. 13181. （第一作者,，JCR一區(qū)，IF: 6.208）
[4].Yuanyuan Zhou*, Cheng Zhang, Zhongguo Zhou, Chao Zhang, Jiali Wang, Identification of key genes and pathways associated with Pizeo1 in bone-related disease based on bioinformatic, International Journal of Molecular Sciences, 2022, 23, 5250.（第一作者及第一通訊,，JCR一區(qū),，IF: 6.208）
[5].Yuanyuan Zhou, Po-yee Chung, Jessica Yuen Wuen Ma, Alfred Kin-yin, Lam, Simon Law, Kwok Wah Chan, Albert Sun-chi Chan, Xingshu Li, Kim-hung Lam, Chung-hin Chui, Johnny Cheuk-on Tang. Development of a novel quinoline derivative as p-glycoprotein inhibitor to reverse multi-drug resistance in cancer cells, Biology, 2019, 8(4), 75. （第一作者，JCR一區(qū),，IF: 5.168）
[6].Zhao Xibang, Zhou Yuanyuan, Li Jianting, Zhang Chao, Wangl Jiali, Opportunities and challenges of hydrogel microspheres for tendong-bone healing after anterior cruciate ligament reconstruction, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2021, 110(2). （共同一作,，JCR二區(qū)，IF: 3.405）
[7].Dessy Chan, Yuanyuan Zhou, Chung Hin Chui, Kim Hung Lam, Simon Law, Albert Sun-chi Chan, Xingshu Li, Alfred King-yin Lam, and Johnny Cheuk On Tang. Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma, Cells, 2018 Oct; 7(10): p.15. (共同一作,，JCR一區(qū),，IF: 7.666)
[8].Yan Liang, Yuanyuan Zhou, Lin Xie, Jingwei Zhang, Yanna Liu, Tianye Guan, Yu Wang, Lu Xing, Tai Rao, Lijun Zhou, Kun Hao. In Vitro to In Vivo Evidence of the Inhibitor Characteristics of Schisandra Lignans toward P-Glycoprotein. Phytomedicine，2013,，1030-1038. (共同一作,，JCR一區(qū)，IF: 6.656)
[9].Yan Liang, Yuanyuan Zhou, Yanna Liu, Tianye Guan, Xiao Zheng, Chen Dai, Lu Xing, Tai Rao, Lin Xie, Guangji Wang. Study on the plasma protein binding rate of Schisandra lignans based on the LC-IT-TOF/MS technique with relative quantitative analysis. Chinese journal of natural medicines,，2013, 11(4): 0442-0448. (共同一作,，JCR二區(qū)，IF: 3.887)
[10]. Chen Zhang, Zhengxiang Cheng, Yuanyuan Zhou, Ziyi Yu, Hongyu Mai, Changhao Xu, Jing Zhang, Jiali Wang. The novel hyaluronic acid granular attenuates osteoarthritis progression by inhibiting the TLR-2/NF-B signaling pathway through suppressing cellular senescence. Bioengineering & Translational Medicine, 2022, e10475. (JCR一區(qū),，IF: 10.26)
[11].Po Yee Chung, Pik Ling Lam, Yuanyuan Zhou, Jessica Gasparello, Alessia Finotti, Adriana Chilin, Giovanni Marzaro, Roberto Gambari, Zhaoxiang Bian, Wai Mink Kwok, Wai Yeung Wong, Xi Wang, Alfred King-yin Lam, Albert Sun-chi Chan, Xingshu Li, Jessica Yuen Wuen Ma, Chung Hin Chui, Kim Hung Lam, Johnny Cheuk On Tang. Targeting DNA Binding for NF-B as an Anticancer Approach in Hepatocellular Carcinoma. Cells, 2018, 7(10), 177. (JCR一區(qū),，IF: 7.666)
[12].Ivan Ho Yuen Pan, Dessy, Chan, Sau Hing Chan, Po Yee Chung, Yuanyuan Zhou, Simon Law, Alfred King Yin Lam, Chung Hin Chui, Albert Sun Chi Chan, Kim Hung Lam, Johnny Cheuk On Tang. Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma Through Down-Regulation of COX-2 mRNA and PGE2. Cancer Research and Treatment, 2017, 49(1), 219-229. (JCR二區(qū)，IF: 5.036)
[13].Yan Liang, Yuanyuan Zhou, Jingwei Zhang, Tai Rao, Lijun Zhou, Rong Xing, Qian Wang, Hanxu Fu, Kun Hao, Lin Xie, Guangji Wang. Pharmacokinetic Compatibility of Ginsenosides and Schisandra Lignans in Shengmai-san: From the Perspective of P-Glycoprotein. PLoS ONE, 2014, 9(6), e98717. (JCR二區(qū),，IF: 3.752)
[14]. Xiao Zheng, Yan Liang, An Kang, Sijing Ma, Lu Xing, Yuanyuan Zhou, Chen Dai, Hao Xie, Lin Xie, Guangji Wang, Haiping Hao. Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats. Neuroscience, 2014, 256, 210-222. (JCR三區(qū),，IF: 3.708)
[15].Yanna Liu, Yan Liang, Yuanyuan Zhou, Tianye Guan, Lu Xing, Tai Rao, Lijun Zhou, Xiaoyi Yu, Qian Wang, Lin Xie, Guangji Wang. Experimental Evidence for Ion Accumulation Time Affecting Qualitative and Quantitative Analysis of Ophiopogons in Ophiopogon Extract by Hybrid Ion Trap Time-of-Flight Mass Spectrometry. Chromatographia, 2013, 76: 949-958. (JCR三區(qū)，IF: 2.213)
[16]. Chen Dai, Yan Liang, Haiping Hao, Xiao Zheng, Lin Xie, Tianye Guan, Yuanyuan Zhou, Guangji Wang. Global detection and identification of components from Yunnan Baiyao based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry. Journal of Separation Science. 2013, 36, 1935-1944. (JCR二區(qū),，IF: 3.614)
[17]. Yan Liang, Tianye Guan, Yuanyuan Zhou, Yanna Liu, Lu Xing, Xiao Zheng, Chen Dai, Ping Du, Tai Rao, Lijun Zhou, Xiaoyi Yu, Lun Hao, Lin Xie, Guangji Wang. Effect of mobile phase additives on qualitative and quantitative analysis of ginsenosides by liquid chromatography hybrid quadrupole-time of flight mass spectrometry. Journal of Chromatography A, 2013, 1297, 29-36. (JCR一區(qū),，IF: 4.601)
[18]. Tong Xie, Yan Liang, Jiye A, Haiping Hao, Linsheng Liu, Xiao Zheng, Chen Dai, Yuanyuan Zhou, Tianye Guan, Yanna Liu, Lin Xie, Guangji Wang. Post acquisition data processing techniques for lipid analysis by quadrupole time-of-flight mass spectrometry. Journal of Chromatography B, 2012, 905, 43-53. (JCR二區(qū)，IF: 3.318)
[19]. Yan Liang, Wei Xiao, Chen Dai, Lin Xie, Gang Ding, Guangji Wang, Zhaoping Meng, Juan Zhang, An Kang, Tone Xie, Yuanna Liu, Yuanyuan Zhou, Wenjun, Liu, Li Zhao, Jia Xu. Structural identification of the metabolites for strictosamide in rats bile by an ion trap-TOF mass spectrometer and mass defect filter technique. Journal of Chromatography B, 2011, 879, 1819-1822. (JCR二區(qū),，IF: 3.318)
專利成果
[1]. 王佳力; 張晨; 周媛媛,，一種新型模擬肥胖人群膝骨關(guān)節(jié)炎動(dòng)物模型及其建立方法和應(yīng)用,國(guó)家發(fā)明專利，CN202110540938.2,，2022年9月13日授權(quán),。
