趙孟孟(碩士生導(dǎo)師)
姓名: 趙孟孟
性別: 男
職稱: 副教授
教育與工作簡(jiǎn)歷:
2005.9-2009.6河南農(nóng)業(yè)大學(xué) 牧醫(yī)工程學(xué)院 本科 藥物制劑
2009.9-2011.6華南農(nóng)業(yè)大學(xué) 獸醫(yī)學(xué)院 基礎(chǔ)獸醫(yī)學(xué) 導(dǎo)師:馬春全(碩博連讀)
2011.9-2014.6華南農(nóng)業(yè)大學(xué) 獸醫(yī)學(xué)院 預(yù)防獸醫(yī)學(xué) 導(dǎo)師:張桂紅
2014年7月– 2016年11月 河南農(nóng)業(yè)大學(xué) 博士后 合作導(dǎo)師:張改平
2016年12月-2018年2月 美國(guó)俄克拉荷馬州立大學(xué) 博士后 合作導(dǎo)師:李師弢
2018年3月– 2020年7月 美國(guó)杜蘭大學(xué) 博士后 合作導(dǎo)師:林震
2020年10月–至今 佛山科學(xué)技術(shù)學(xué)院
主要研究?jī)?nèi)容和研究成果:
主要研究方向?yàn)閯?dòng)物傳染病與人獸共患病,,致力研究豬繁殖與呼吸綜合征病毒,、流感病毒致病機(jī)理。研究成果以第一作者/通訊作者在領(lǐng)域國(guó)際權(quán)威期刊 Journal of Virology,,Journal of Molecular Cell Biology,,Microorganisms,,International Journal of Molecular Sciences,Veterinary Immunology and Immunopathology等發(fā)表論文50余篇,。主持國(guó)家自然科學(xué)基金青年基金1項(xiàng),,廣東省教育廳項(xiàng)目1項(xiàng),廣東省動(dòng)物源性人獸共患病預(yù)防與控制重點(diǎn)實(shí)驗(yàn)室開放課題1項(xiàng),,參與6項(xiàng),。
教學(xué)與人才培養(yǎng):
承擔(dān)本科生《獸醫(yī)微生物學(xué)》、《獸醫(yī)微生物學(xué)與免疫學(xué)實(shí)驗(yàn)技術(shù)》,、《家畜傳染病學(xué)》,,研究生《文獻(xiàn)檢索與知識(shí)產(chǎn)權(quán)》、《動(dòng)物疫病防控》課程,。指導(dǎo)的21級(jí)研究生沙惠陽(yáng)獲得2022年研究生國(guó)家獎(jiǎng)學(xué)金,,21級(jí)研究生張航獲得2023年研究生國(guó)家獎(jiǎng)學(xué)金,22級(jí)研究生羅琴2023年研究生國(guó)家獎(jiǎng)學(xué)金,。
社會(huì)兼職:
無(wú)
代表性科研項(xiàng)目:
1. 國(guó)家自然科學(xué)基金青年基金-TRIM4泛素化NSP2調(diào)控PRRSV復(fù)制研究,,項(xiàng)目批準(zhǔn)號(hào):31902279,2020年1月至2022年12月,,24萬(wàn),,結(jié)題,主持
2. 廣東省教育廳特色創(chuàng)新項(xiàng)目,,豬繁殖與呼吸綜合征病毒逃逸三基序蛋白21抗病毒作用的分子機(jī)制研究,,2023.10-2025.9,在研,,主持
3. 廣東省動(dòng)物源性人獸共患病預(yù)防與控制重點(diǎn)實(shí)驗(yàn)室開放課,,2021年1月-12月
4. 國(guó)家自然科學(xué)基金重大項(xiàng)目–豬繁殖與呼吸綜合征病毒入侵和感染機(jī)制的分子機(jī)制,項(xiàng)目批準(zhǔn)號(hào):31490601,2014年12月至2019年12月,,600萬(wàn),,結(jié)題,參與
5. 國(guó)家自然科學(xué)基金面上項(xiàng)目–豬繁殖與呼吸綜合征病毒非結(jié)構(gòu)蛋白NSP9功能研究,,項(xiàng)目批準(zhǔn)號(hào):31272564,82萬(wàn),,2013年1月至2016年12月,,結(jié)題,參與
6. 國(guó)家級(jí)自然科學(xué)基金面上項(xiàng)目:巴泰病毒利用磷酯酰絲氨酸受體Tyro3入侵并劫持宿主細(xì)胞凋亡的分子機(jī)制,,項(xiàng)目批準(zhǔn)號(hào):32273097,,54萬(wàn)元,2023年1月–2026年12月,,在研,,參與
7. 豬病毒性腹瀉診斷技術(shù)與防控制劑研究開發(fā)(KH22293),佛山市佛丹動(dòng)物藥業(yè)有限公司,,2022年11月,,排名第2, 200萬(wàn),,在研,,參與
8. 國(guó)家自然科學(xué)基金青年基金–肌醇多磷酸磷酸酶(SHIP-1)在PRRSV逃逸宿主體液免疫應(yīng)答中的作用機(jī)制研究,項(xiàng)目批準(zhǔn)號(hào):31502040,,2016年1月至2018年12月,,21萬(wàn),結(jié)題,,參與
9. 國(guó)家自然科學(xué)基金青年基金–豬繁殖與呼吸綜合征NSP7主要抗原表位篩選,,項(xiàng)目批準(zhǔn)號(hào):31201876, 2013年1月至2015年12月,,21萬(wàn),,結(jié)題,參與
發(fā)表論文
第一作者
[1] Mengmeng Zhao, Asuka Nanbo, David Becnel, Zhiqiang Qin, Gilbert F. Morris, Li Li, and Zhen Lin* , Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta, Journal of Virology, 2020, 94(22): e01298-20.
[2] Mengmeng Zhao#, Kun Song#, Wenzhuo Hao#, Lingyan Wang, Girish Patil, Qingmei Li, Lingling Xu, Fang Hua, Bishi Fu, Jens C, Schwamborn, Martin E. Dorf, Shitao Li*, Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway [J], Journal of Molecular Cell Biology, 2020,12(3):163-175.
[3] Mengmeng Zhao, Huiyang Sha, Hang Zhang, Ruining Wang. Interferon inducible porcine 2′, 5′-oligoadenylate synthetase like-1 protein limits porcine reproductive and respiratory syndrome virus 2 infections via the MDA5-mediated interferon-signaling pathway. International Immunopharmacology. 2022,111:109151.
[4] Mengmeng Zhao, Huiyang Sha, Hang Zhang, Ruining Wang. TRIM4-mediated ubiquitination of NSP2 restricts porcine reproductive and respiratory syndrome virus proliferation. BMC Veterinary Research, 2022, 18(1):208.
[5] Mengmeng Zhao, Huawei Li, Hang Zhang, Huiyang Sha, Liangzong Huang, Ruining Wang. Sequence Analysis of Macaca mulatta TRIM4 and Its Role in the Interferon Pathway, Frontiers in Veterinary Science, 2022 , 9:805301.
[6] Mengmeng Zhao, Hang Zhang, Huiyang Sha, Huawei Li, Ruining Wang, Molecular cloning and functional analysis of Macaca mulatta STING, Developmental and Comparative Immunology, 2022, 127, 104296.
[7] Mengmeng Zhao, Asuka Nano, Lichun Sun, Zhen Lin*, Extracellular Vesicles in Epstein-Barr virus’ Life Cycle and Pathogenesis [J], Microorganisms, 2019, 7(2): E48.
[8] Mengmeng Zhao, Lingyan Wang, Shitao Li*, Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis[J], International Journal of Molecular Sciences, 2017, 18(8): 1673.
[9] Mengmeng Zhao#, Bo Wan#, Huawei Li, Jian He, Xinxin Chen, Linjian Wang, Yinbiao Wang, Sha Xie, Songlin Qiao*, Gaiping Zhang*, Porcine 2′,5′-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro [J], Microbial Pathogenesis, 2017, 111: 14-21.
[10] Mengmeng Zhao, Juanjuan Qian, Jiexiong Xie, Tiantian Cui, Songling Feng, Guoqiang Wang, Ruining Wang, Guihong Zhang*, Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive and respiratory syndrome virus [J], Frontiers of Agricultural Science and Engineer, 2016, 3(2):153-160.
[11] Mengmeng Zhao#, Zhangyong Ning#, Heng Wang, Zhen Huang, Minze Zhang, Guihong Zhang*, Sequence analysis of NSP9 gene of 25 PRRSV strains from Guangdong province, subtropical southern China [J], Virus Genes, 2013, 46:88-96.
通訊作者
1. Hang Zhang, Qin Luo, Yajie Zheng, Huiyang Sha, Gan Li, Weili Kong, Liangzong Huang, Mengmeng Zhao*. Genetic Variability and Recombination of the NSP2 Gene of PRRSV-2 Strains in China from 1996 to 2021. Veterinary Sciences, 2023, 10(5):325.
2. Xiuqiao Chen, Jinghua Pan, Liangzong Huang*, Mengmeng Zhao*. Research Progress on the E Protein of Porcine Reproductive and Respiratory Syndrome Virus. Frontiers in Microbiology, 2023, 14:11139628.
3. Jinghua Pan, Mengyi Zeng, Mengmeng Zhao*, Liangzong Huang*, Research Progress on the Detection Methods of Porcine Reproductive and Respiratory Syndrome Virus [J], Frontiers in Microbiology, 2023, 14:1097905.
4. Qin Luo , Yajie Zheng, Hang Zhang, Zhiyu Yang, Huiyang Sha, Weili Kong, Mengmeng Zhao,* and Nina Wang,*. Research progress on glycoprotein 5 of porcine reproductive and respiratory syndrome virus[J], Animals, 2023, 13(5):813
5. Huiyang Sha+, Hang Zhang+, Qin Luo+, Yajie Zheng+, Qingge Zhu+, Nina Wang, Limei Qin, Huawei Li, Liangzong Huang*, Mengmeng Zhao*, Variations in the NSP4 gene of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus Isolated in China from 1996 to 2021, Virus Genes, 2023, 59:109-120.
6. Huiyang Sha, Hang Zhang, Yao Chen, Liangzong Huang, Mengmeng Zhao, Nina Wang. Research Progress on the NSP9 Protein of Porcine Reproductive and Respiratory Syndrome Virus. Frontiers in Veterinary Science, 2022 ,2(15), 9:805301.
7. Hang Zhang, Huiyang Sha, Limei Qin, Nina Wang, Weili Kong, Liangzong Huang, and Mengmeng Zhao. Research Progress in Porcine Reproductive and Respiratory Syndrome Virus–Host Protein Interactions. Animals, 2022, 12: 1381.
8. Zhihai Shi, Wenjia Wang, Zhaoxue Xu, Mengmeng Zhao*, Yali Lan*,Detection and Molecular Characterization of BCoVs Circulating in Central China Based on the Full-length S Gene,,Kafkas Universitesi Veteriner Fakultesi Dergisi, 2020,26(2):180-186.
9. RuiningWang, YinfengKang, Huawei Li, Hongfang Ma, Wenjia Wang, Yanfen Cheng, Pengchao Ji, Erqin Zhang, Mengmen Zhao*, Molecular cloning and functional characterization of porcine 2′,5′-oligoadenylate synthetase 1b and its effect on infection with porcine reproductive and respiratory syndrome virus [J], Veterinary Immunology and Immunopathology, 2019, 209(3): 22-30.
10. RuiningWang, Yi Yu, Weili Kong, Cunfa Li, Yinfeng Kang, Guoqiang Wang, Wenji Wang, Jian He, Mengmeng Zhao*, Molecular cloning of porcine 2′,5′-oligoadenylate synthetase-like protein and its role in porcine reproductive and respiratory syndrome virus infection [J], Microbial Pathogenesis, 2018, 125: 281-289.
11. Ruining Wang, Hongfang Ma, Yinfeng Kang, Cunfa Li, Huawei Li, Erqin Zhang, Pengchao Ji, Jian He, Mengmeng Zhao*, Molecular Cloning and Identification of the 2′,5′ Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection [J], Indian Journal of Microbiology, 2018, 58(3): 332-344.
12. Huawei Li, Qin Luo, Huiyuan Jing, Yuzhen Song, Weili Kong, Mengmeng Zhao* and Qingge Zhu* Research Progress on Porcine Reproductive and Respiratory Syndrome Virus NSP7 Protein, Animals, 2023, 13, 2269.
13. Zhiqing Zhang, Hang Zhang, Qin Luo, Yajie Zheng, Weili Kong, Liangzong Huang*, Mengmeng Zhao*. Variations in NSP1 of Porcine Reproductive and Respiratory Syndrome Virus Isolated in China from 1996 to 2022.Genes, 2023, 14(7), 1435.
14. Hang Zhang, Qin Luo, Yingxin He, Yajie Zheng, Huiyang Sha, Gan Li, Weili Kong, Jiedan Liao *, Mengmeng Zhao*. Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines. Veterinary Science. 2023, 10, 491.
15. Qin Luo , Yajie Zheng , Gan Li , Hang Zhang , Huiyang Sha , Zhiqing Zhang, Liangzong Huang *, Mengmeng Zhao *. Genetic Variation and Recombination Analysis of the GP5 (GP5a) Gene of PRRSV-2 Strains in China from 1996 to 2022. [J], Frontiers in Microbiology, 2023, 14, 1238766.
并列第一作者
1. Fayer Heir#, Mengmeng Zhao#, Michael J. Strong#, Yi Yu#, Asuka Nano, Erik K. Flemington, Gilbert F. Morris, Krzysztof Ress, Li Li, Zhen Lin*, Detection of Epstein-Barr Virus Infection in Non-Small Cell Lung Cancer [J], Cancers, 2019,11(6): 759.
2. Girish Patil#, Mengmeng Zhao#, Kun Song#, Wenzhuo Hao, Daniel Bouchereau, Lingyan Wang, Shitao Li*, TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection [J], Journal of Virology, 2018, 92(16): e00905-18.
3. Bishi Fu#, Mengmeng Zhao#, Lingyan Wang, Girish Patil, Jennifer A. Smith, Ignacio J. Juncadella, Ljiljana Zuvela-Jelaska, Martin E. Dorf*, and Shitao Li*, RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling [J], Scientific Reports, 2017, 7(1): 2683.
學(xué)術(shù)兼職
Journal of Virology,、Iscience、Virus Evolution,、Viruses,、Gene、Frontiers in Veterinary Science,、Life,、Vaccines、Transboundary and Emerging Diseases、Veterinary Sciences,、Diagnostics,、BMC Veterinary Science、European Journal of Medical Research,、Pathogens,、Vaccines、Animals,、IJMS,、Microorganisms、《中國(guó)畜牧獸醫(yī)》等雜志審稿人,,Zoonoses,, Veterinary Vaccine青年編委,國(guó)家自然科學(xué)基金同行評(píng)審專家,。Reviewer Board of Veterinary Sciences雜志,,Frontiers in Veterinary Science雜志客座編輯。
聯(lián)系方式:
通信地址:廣東省佛山市南海區(qū)廣云路33號(hào),,佛山科學(xué)技術(shù)學(xué)院B7樓109室,,郵編:528225
郵箱:[email protected],微信zmm20131023